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What is thyroiditis?

Thyroiditis is an inflammation on the thyroid gland and the most common cause of hypothyroidism. When patients with thyroiditis have any symptoms, they are usually the symptoms of hypothyroidism. It’s also common to have an enlarged thyroid that may shrink over time. The type of thyroiditis seen most often is Hashimoto’s thyroiditis, a painless disease of the

immune system that runs in families. Hashimoto's thyroiditis affects about 5% if the adult population, increasing particularly in women as they age.

The thyroid is the largest gland in the neck. It produces, secretes, and stores thyroxine (T4), a hormone that influences the metabolism of just about every body process. When the thyroid gland is functioning properly, hormone release is carefully regulated. When bacteria or viruses invade and inflame the gland, T4 surges into the bloodstream and raises hormone levels that then discourage the gland from creating more T4. Eventually the hormone stores are exhausted, the thyroid loses its ability to manufacture T4, and an underactive thyroid (hypothyroidism) results. This condition is more common in women than in men and usually develops between ages 30-50.

The thyroid gland usually contains an abundance of thyroid hormone that is stored in follicles and released when needed. Inflammation of the thyroid, termed thyroiditis, may result in uncontrolled release of thyroid hormone from the inflamed gland, leading to hyperthyroidism. The inflammation may be silent and non-painful, and patients may be unaware that the thyroid gland is affected by the inflammatory process. Thyroiditis also commonly occurs after pregnancy, and hence may be referred to in this instance as ‘postpartum thyroiditis’.

Alternatively, thyroid inflammation may be quite severe and painful (subacute thyroiditis), producing local neck discomfort, neck tenderness, difficulty with swallowing and symptoms of systemic inflammation, including fatigue, fever, loss of appetite and weight loss. With both types of thyroiditis, the inflammation can produce some degree of thyroid enlargement, which can be particularly prominent with subacute thyroiditis.

If enough thyroid hormone is released from the inflamed thyroid gland, mild to severe hyperthyroidism may develop, that can last for weeks to months. Following the resolution of thyroiditis, the thyroid gland often begins to function normally again, and no further treatment may be necessary. If the inflammation has produced significant permanent damage to the thyroid, the gland may not be able to function normally after the inflammation has subsided, and hypothyroidism may ensue.

More information on thyroiditis

What is thyroiditis? - Thyroiditis is an inflammation on the thyroid gland and the most common cause of hypothyroidism.
What is Hashimoto's thyroiditis? - Hashimoto's thyroiditis often begins with a painless, firm enlargement of the thyroid gland or a feeling of fullness in the neck.
What is subacute thyroiditis? - Subacute thyroiditis is a painful inflammation that develops suddenly in a patient who has had a viral infection.
What is silent thyroiditis? - Silent thyroiditis is characterized by rigidity and slight enlargement of the thyroid gland.
What is postpartum thyroiditis? - Postpartum thyroiditis occurs frequently in women with a past history of thyroid disease who have recently delivered a baby.
How is thyroiditis diagnosed? - Thyroiditis is diagnosed through a careful medical history, physical examination, and measurement of blood tests.
What're the treatments for thyroiditis? - Treatment of thyroiditis include the use of beta blockers and antithyroid drugs.
Endocrine disorders Mainpage

Topics in endocrine disorders

Adrenal insufficiency
Addison's disease
Congenital adrenal hyperplasia
Conn's syndrome
Cushing's syndrome
Nelson's syndrome
Bartter's syndrome
Adrenocortical carcinoma
Pituitary gland disorders
Thyroid gland disorders

All information is intended for reference only. Please consult your physician for accurate medical advices and treatment. Copyright 2005,, all rights reserved. Last update: July 18, 2005