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All about Conn's syndrome (primary hyperaldosteronism) causes of Conn's syndrome symptoms of Conn's syndrome (primary hyperaldosteronism) diagnosis of Conn's syndrome treatments for Conn's syndrome

What are the symptoms of Conn's syndrome (primary hyperaldosteronism)?

Symptoms of Conn's syndrome include high blood pressure, headache, tiredness, and excessive urination (often during the night). Also, the level of potassium in the blood may be decreased. Other symptoms may occur because high aldosterone levels in the blood act on the kidney to increase the loss of the mineral potassium in the urine. This in turn may lead to a fall

in blood potassium, resulting in tiredness, muscle weakness and passing of large volumes of urine (polyuria), especially at night (nocturia). However, these symptoms are also found in many other conditions (for example, diabetes mellitus or hypercalcaemia) and do not, by themselves, establish a diagnosis of Conn's syndrome. Also, many patients with proven Conn's syndrome do not have a low blood potassium level.

In hyperaldosteronism, excess aldosterone leads to an inappropriate salt reabsorption, which increases the extracellular fluid volume until the kidneys can respond appropriately. Patients typically have mild to moderate hypertension. Primary hyperaldosteronism can be distinguished from basic hypertension through blood tests. In general, hyperaldosteronism is unresponsive to standard medical therapy used to prevent or reduce high blood pressure.

Mild hypernatremia (high blood sodium), hypokalemia (low blood potassium), hyperkaluria (high urine potassium) and high levels of alkalinity are the electrolyte abnormalities commonly seen with excess aldosterone. These contribute the following symptoms: muscle weakness, frequent urination, nighttime urination, headache, excessive thirst, pins and needles sensation, visual disturbances, temporary paralysis, muscle twitching and cramps. The severity of these symptoms may be highly variable depending on the degree of electrolyte abnormality.

More information on Conn's syndrome (primary hyperaldosteronism)

What is Conn's syndrome? - Conn's syndrome is a disease of the adrenal glands involving excess production of a hormone, called aldosterone. Another name for the condition is primary hyperaldosteronism.
What causes primary hyperaldosteronism? - The most common cause of Conn's syndrome is an aldosterone-producing tumor of the adrenal gland.
What are the symptoms of Conn's syndrome - Symptoms of Conn's syndrome include high blood pressure, headache, tiredness, and excessive urination (often during the night).
How is Conn's syndrome diagnosed? - Conn's syndrome should be suspected in all patients with high blood pressure. The most rigorous method of diagnosis is to measure the blood levels of two hormones.
What're the treatments for Conn's syndrome? - Conn's syndrome resulting from a tumor is usually treated by removing an adrenal gland (unilateral adrenalectomy). 
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Topics in endocrine disorders

Adrenal insufficiency
Addison's disease
Congenital adrenal hyperplasia
Conn's syndrome
Cushing's syndrome
Nelson's syndrome
Bartter's syndrome
Adrenocortical carcinoma
Pituitary gland disorders
Thyroid gland disorders

All information is intended for reference only. Please consult your physician for accurate medical advices and treatment. Copyright 2005,, all rights reserved. Last update: July 18, 2005