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Adrenal insufficiency

Adrenal insufficiency refers to the inability of the adrenal glands to produce a normal quantity of hormones. It may also be defined as a reduced ability to cope with stress. It is one of the most common imbalances in our population today. Adrenal insufficiency is not to be confused with Addison's disease. Addison's disease is more or less a total adrenal gland

shutdown. Adrenal insufficiency is also different from adrenal burnout. The latter is a more severe derangement of the energy-producing mechanisms of the body. In burnout, the body is basically unable to cope with stress. The symptoms of burnout are similar to those of adrenal insufficiency, but are more extreme and require longer to correct.

Adrenal insufficiency is a life-threatening condition caused by the disrupted functioning of the adrenal gland called the cortex. The condition causes decreased production of two important hormones normally released by the cortex, cortisol and aldosterone. Infection or hemorrhaging of the gland often results, and all functions of the gland are lost. Adrenal insufficiency occurs in about four in every 100,000 people. The condition can strike both men and women of all ages, but is more common in middle-aged women.

Patients diagnosed with adrenal insufficiency typically experience fatigue and loss of energy, loss of appetite, nausea, vomiting, diarrhea, abdominal pain, weight loss, muscle weakness, dizziness when standing, dehydration, anxiety and depression. The patient may also notice increased bronze pigmentation of the skin and mucous membranes and decreased tolerance to cold. Women lose pubic and underarm hair and stop having normal menstrual periods. Unfortunately, significant symptoms are usually not noticed until about 90% of the adrenal cortex has been destroyed.

Many people do not recognize the slow progression of symptoms of adrenal insufficiency and it is ultimately identified when a doctor notices the areas of increased pigmentation of the skin. A doctor will run laboratory blood tests to reveal abnormally low blood concentrations of sodium and glucose, a greater than normal level of serum potassium, and a decreased urinary output of certain steroids. The doctor will diagnosis adrenal insufficiency if the amount of cortisol in the plasma and steroid in the urine does not increase after the patient takes a synthetic steroid.

Treatment of adrenal insufficiency includes replacing missing or low levels of cortisol with synthetic steroids such as glucocorticoid, adrenal genital corticoids, and mineralocorticoid drugs. Patients with adrenal insufficiency will need to take a steroid by mouth for the rest of their lives. Resulting dehydration and salt loss should be treated with an adequate fluid intake and a diet high in complex carbohydrate and protein. Dangerously low blood pressure may require special medications to safely elevate it until the steroids take effect. Follow-up care includes frequent monitoring of blood sugar and urinary acetone levels and continued administration of the steroids.

Early diagnosis and treatment for patients diagnosed with adrenal insufficiency will usually be life-saving. However, patients need to be aware of the significance of emotional distress, the value of wearing a medical-alert bracelet or tag, the signs of impending crisis, the use of a prepared kit for emergencies, and the importance of careful attention to drug use and diet. In addition, steroid replacements should only be taken after meals or with milk to prevent gastric irritation and the development of ulcers. Most patients following treatment can expect to enjoy a fully active life and normal lifespan.

Endocrine disorders Mainpage

Topics in endocrine disorders

Adrenal insufficiency
Addison's disease
Congenital adrenal hyperplasia
Conn's syndrome
Cushing's syndrome
Nelson's syndrome
Bartter's syndrome
Adrenocortical carcinoma
Pituitary gland disorders
Thyroid gland disorders

All information is intended for reference only. Please consult your physician for accurate medical advices and treatment. Copyright 2005,, all rights reserved. Last update: July 18, 2005